X0306 4 2022-01-18 0 0001620463 Athira Pharma, Inc. ATHA 0001822494 MOEBIUS HANS C/O ATHIRA PHARMA, INC. 18706 NORTH CREEK PARKWAY, SUITE 104 BOTHELL WA 98011 0 1 0 0 Chief Medical Officer Common Stock 2021-11-18 5 A 0 E 829 12.51 A 31256 D Stock Option (Right to Buy) 10.64 2022-01-18 4 A 0 180000 0.00 A 2032-01-17 Common Stock 180000 180000 D The reporting person is voluntarily reporting the acquisition of shares of the issuer's common stock pursuant to the Athira Pharma, Inc. 2020 Employee Stock Purchase Plan ("ESPP"), for the ESPP Purchase Period (as defined in the ESPP) of May 18, 2021 through November 18, 2021. This transaction is also exempt under Rule 16b-3(c). The Purchase Period ended November 18, 2021 and is the Purchase Period comprising the Offering Period (as defined in the ESPP) that began May 18, 2021. In accordance with the ESPP, these shares were purchased based on 85% of the closing price on November 18, 2021. One forty-eighth (1/48th) of the shares subject to the option will vest on February 18, 2022, and one forty-eighth of the shares subject to the option will vest each month thereafter. /s/ Glenna Mileson, Attorney-in-fact for Hans Moebius 2022-01-20