X0306 4 2019-09-20 0 0001582313 Xenon Pharmaceuticals Inc. XENE 0001620084 PIMSTONE SIMON N. 200 - 3650 GILMORE WAY BURNABY A1 BRITISH COLUMBIA, CANADA 1 1 0 0 CEO Common Shares 2019-09-20 4 S 0 10395 9.51 D 258122 D Common Shares 16460 I Spouse The "Amount" and "Price" reported in this Column 4 reflect the aggregate number and weighted-average price, respectively, of shares sold. These shares were sold in multiple transactions at prices ranging from $9.50 to $9.60, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein /s/ Sherry Aulin, Attorney-in-fact 2019-09-24