Fair Value Measurements and Fair Value of Financial Instruments - Schedule of Fair Value and Amortized Cost of Cash Equivalents and Available-for-Sale Marketable Securities (Details) - USD ($) $ in Thousands	Mar. 31, 2022	Dec. 31, 2021
Debt Securities, Available-for-sale [Line Items]
Amortized Cost Basis	$ 391,911	$ 413,643
Unrealized Gain	7	6
Unrealized Loss	(1,095)	(141)
Estimated Fair Value	390,823	413,508
Cash and Cash Equivalents [Member]
Debt Securities, Available-for-sale [Line Items]
Estimated Fair Value	147,630	240,420
Marketable Securities, Short-Term [Member]
Debt Securities, Available-for-sale [Line Items]
Estimated Fair Value	206,101	135,412
Marketable Securities, Long-Term [Member]
Debt Securities, Available-for-sale [Line Items]
Estimated Fair Value	37,092	37,676
Commercial Paper
Debt Securities, Available-for-sale [Line Items]
Amortized Cost Basis	129,544	141,726
Unrealized Gain	3	1
Unrealized Loss	(178)	(51)
Estimated Fair Value	129,369	141,676
U.S. Treasury Bills [Member]
Debt Securities, Available-for-sale [Line Items]
Amortized Cost Basis	110,867	26,626
Unrealized Gain	1	1
Unrealized Loss	(510)	(37)
Estimated Fair Value	110,358	26,590
Money Market Investments (Included in Cash and Cash Equivalents)
Debt Securities, Available-for-sale [Line Items]
Amortized Cost Basis	64,730	181,528
Estimated Fair Value	64,730	181,528
Corporate Debt Securities
Debt Securities, Available-for-sale [Line Items]
Amortized Cost Basis	64,479	38,661
Unrealized Gain	3	4
Unrealized Loss	(275)	(16)
Estimated Fair Value	64,207	38,649
Us Government Agency Bonds [Member]
Debt Securities, Available-for-sale [Line Items]
Amortized Cost Basis	22,291	25,102
Unrealized Loss	(132)	(37)
Estimated Fair Value	$ 22,159	$ 25,065