X0306 4 2020-01-23 0 0001680581 Fulcrum Therapeutics, Inc. FULC 0001619846 Stuart Bryan C/O FULCRUM THERAPEUTICS, INC. 26 LANDSDOWNE STREET CAMBRIDGE MA 02139 0 1 0 0 Chief Operating Officer Stock Option (right to buy) 16.87 2020-01-23 4 A 0 105000 0.00 A 2030-01-22 Common Stock 105000 105000 D This option was granted on January 23, 2020 and is scheduled to vest in equal quarterly installments over four years beginning on the vesting commencement date of January 1, 2020, subject to continued service. /s/ Peter Thomson, as attorney-in-fact for Bryan Stuart 2020-01-27