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Commitments and Contingencies - Additional Information (Details)			3 Months Ended
	Apr. 16, 2018 USD ($)	Aug. 26, 2008	Mar. 31, 2019 USD ($) lease	Mar. 31, 2018 USD ($)	Dec. 31, 2018 USD ($)
Commitments and Contingencies Disclosure [Abstract]
Rent, lease amortization and interest expense			$ 100,000
Rent, lease amortization and interest expense				$ 100,000
Weighted average discount rate			9.00%
Remaining term on lease liabilities			4 years 7 months 6 days
Number of leases \| lease			2
Assets under capital lease			$ 400,000
Capital lease interest expense obligation			100,000
Gross fixed assets for capital leases				$ 300,000
Accumulated depreciation			100,000
Commitments And Contingencies [Line Items]
Initial term of agreement	3 years
Bio Valve
Commitments And Contingencies [Line Items]
Upfront license, signing fees and development milestone payments		9.00%
Upfront license, signing fees and development milestone payments, certain circumstances		10.00%
Amounts owed			$ 0		$ 0
Integration fee
Commitments And Contingencies [Line Items]
Agreement payment	$ 100,000
Annual maintenance fee
Commitments And Contingencies [Line Items]
Agreement payment	$ 100,000