Commitments and Contingencies - Additional Information (Detail) - USD ($)		3 Months Ended		9 Months Ended
	Aug. 22, 2008	Sep. 30, 2016	Sep. 30, 2015	Sep. 30, 2016	Sep. 30, 2015	Dec. 31, 2015
Commitments And Contingencies [Line Items]
Operating lease end year				2017
Rent expense		$ 300,000	$ 400,000	$ 1,000,000	$ 1,000,000
Amounts owed		$ 0		$ 0		$ 0
Bio Valve [Member]
Commitments And Contingencies [Line Items]
Licensing payment	9.00%
Licensing payment	10.00%