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Income Taxes - Reconciliation of Federal Statutory Rate and Effective Tax Rate (Details)
12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Income Tax Disclosure [Abstract]      
Tax expense at federal statutory rate (21.00%) (21.00%) (21.00%)
State income taxes, net of federal tax benefit (5.80%) (11.20%) (3.00%)
Share-based compensation (17.00%) (52.50%) (0.90%)
Section 162(m) of Internal Revenue Code 1.70% 2.30% 1.10%
Research and development credits (8.50%) (10.60%) (7.20%)
Other 0.90% (0.50%) 1.00%
Valuation allowance 49.90% 89.10% 28.60%
Effective tax rate 0.20% (4.40%) (1.40%)