X0306 4 2022-02-10 0 0001616543 Senseonics Holdings, Inc. SENS 0001769791 Kaufman Francine 20451 SENECA MEADOWS PARKWAY GERMANTOWN MD 20876 1 1 0 0 Chief Medical Officer Common Stock 2022-02-10 4 A 0 310884 0.00 A 1386045 D Common Stock 2022-02-11 4 S 0 163870 2.46 D 1222175 D Represents a performance-based restricted stock unit ("RSU") award, which represent a contingent right to receive one share of the Issuer's common stock and vest upon the achievement of certain performance targets, subject to the Reporting Person's continuous service through the vesting events. 100% of the RSUs vested on February 10, 2022 upon the achievement of the performance vesting criteria. Represents shares sold to cover tax obligations upon the vesting of RSUs. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $2.10 to $2.575 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. /s/ Darren K. DeStefano, Attorney-in-Fact 2022-02-14