X0306 4 2021-05-25 0 0001616543 Senseonics Holdings, Inc. SENS 0001827192 Raab Anthony R. C/O SENSEONICS HOLDINGS, INC. 20451 SENECA MEADOWS PARKWAY GERMANTOWN MD 20876 1 0 0 0 Common Stock 2021-05-25 4 A 0 60483 0.00 A 353560 D Common Stock 2021-12-06 4 S 0 136538 2.53 D 217022 D Represents an RSU grant pursuant to the Issuer's non-employee director compensation policy. The RSUs vest in full on the earlier of the one year anniversary of the date of grant or the next annual stockholders meeting, subject to the reporting person's continuous service through such vesting date. Each RSU represents a contingent right to receive one share of the Issuer's common stock. Represents shares sold by the Reporting Person to satisfy the Reporting Person's tax obligations resulting from the settlement of restricted stock units ("RSUs") that vested on October 1, 2021. The sales were effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on November 16, 2021. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $2.50 to $2.62 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. /s/ Darren K. DeStefano, Attorney-in-Fact 2021-12-08