X0306 4 2021-11-15 0 0001616543 Senseonics Holdings, Inc. SENS 0001769791 Kaufman Francine 20451 SENECA MEADOWS PARKWAY GERMANTOWN MD 20876 1 1 0 0 Chief Medical Officer Common Stock 2021-11-15 4 F 0 55531 3.80 D 1096159 D Common Stock 2021-11-16 4 S 0 20998 3.70 D 1075161 D Represents shares withheld to satisfy withholding tax obligations upon the vesting of restricted stock units. Shares were sold pursuant to a Rule 10b5-1 trading plan. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $3.69 to $3.73 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. /s/ Darren K. DeStefano, Attorney-in-Fact 2021-11-18