X0306 4 2021-05-25 0 0001616543 Senseonics Holdings, Inc. SENS 0001270735 ROEDER DOUGLAS A C/O DELPHI VENTURES 160 BOVET ROAD, SUITE 408 SAN MATEO CA 94402 1 0 0 0 Common Stock 2021-05-25 4 S 0 147735 1.91 D 125342 D Common Stock 2021-05-25 4 A 0 60483 0.00 A 185825 D Represents the number of shares sold by the Reporting Person to satisfy the Reporting Person's tax obligations resulting from the settlement of vested restricted stock units ("RSUs") on May 25, 2021. The sales were effected pursuant to a "sell-to-cover" arrangement adopted in accordance with Rule 10b5-1 on March 14, 2021. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $1.87 to $1.96 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. Represents an RSU grant pursuant to the Issuer's non-employee director compensation policy. The RSUs vest in full on the earlier of the one year anniversary of the date of grant or the next annual stockholders meeting, subject to the reporting person's continuous service through such vesting date. Each RSU represents a contingent right to receive one share of the Issuer's common stock. /s/ Darren K. DeStefano, Attorney-in-Fact 2021-05-28