X0306 4 2019-03-04 0 0001616543 Senseonics Holdings, Inc. SENS 0001769791 Kaufman Francine 20451 SENECA MEADOWS PARKWAY GERMANTOWN MD 20876 0 1 0 0 Chief Medical Officer Stock Option (right to buy) 3.07 2019-03-04 4 A 0 550000 0.00 A 2029-03-03 Common Stock 550000 550000 D The exercise price is equal to the closing price of the issuer's common stock on the NYSE American on the date of grant, March 4, 2019. One-fourth of the shares vest on March 4, 2020, with the remaining shares vesting in 36 equal installments at the end of the calendar month for each month after March 4, 2020, subject to the reporting person's continuous service with the issuer as of the applicable vesting date. /s/ Lila L. Inman, Attorney-in-fact 2019-03-06