Exhibit 23.1

Consent of Independent Registered Public Accounting Firm

We consent to the reference to our firm under the caption "Experts" in this Registration Statement (Form F-3) and related Prospectus of Trillium Therapeutics Inc., and to the incorporation by reference therein of our report dated March 5, 2020 with respect to the consolidated financial statements of Trillium Therapeutics Inc., included in its Annual Report (Form 40-F) for the year ended December 31, 2019, filed with the Securities and Exchange Commission.

	/s/ Ernst & Young LLP
Toronto, Canada	Chartered Professional Accountants
April 23, 2020	Licensed Public Accountants