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  <schemaVersion>X0202</schemaVersion>
  <headerData>
    <submissionType>13F-HR</submissionType>
    <filerInfo>
      <liveTestFlag>LIVE</liveTestFlag>
      <flags>
        <confirmingCopyFlag>false</confirmingCopyFlag>
        <returnCopyFlag>false</returnCopyFlag>
        <overrideInternetFlag>false</overrideInternetFlag>
      </flags>
      <filer>
        <credentials>
          <cik>0001615982</cik>
          <ccc>XXXXXXXX</ccc>
        </credentials>
      </filer>
      <periodOfReport>09-30-2025</periodOfReport>
    </filerInfo>
  </headerData>
  <formData>
    <coverPage>
      <reportCalendarOrQuarter>09-30-2025</reportCalendarOrQuarter>
      <filingManager>
        <name> VR ADVISER, LLC</name>
        <address>
          <ns1:street1>7 BRYANT PARK</ns1:street1>
          <ns1:street2>23RD FLOOR</ns1:street2>
          <ns1:city>NEW YORK</ns1:city>
          <ns1:stateOrCountry>NY</ns1:stateOrCountry>
          <ns1:zipCode>10018</ns1:zipCode>
        </address>
      </filingManager>
      <reportType>13F HOLDINGS REPORT</reportType>
      <form13FFileNumber>028-20281</form13FFileNumber>
      <crdNumber>000169288</crdNumber>
      <secFileNumber>801-79382</secFileNumber>
      <provideInfoForInstruction5>Y</provideInfoForInstruction5>
      <additionalInformation>Note: VR Adviser, LLC is filing this Form 13F on behalf of itself and the general partner entities of the investment funds for which it serves as the investment adviser, VHCP Management II, LLC, VHCP Management III, LLC, VHCP Management EG, LLC and Venrock Opportunities Management, LLC.</additionalInformation>
    </coverPage>
    <signatureBlock>
      <name>Sherman G. Souther</name>
      <title>Authorized Signatory</title>
      <phone>650-561-9580</phone>
      <signature>/s/ Sherman G. Souther</signature>
      <city>Palo Alto</city>
      <stateOrCountry>CA</stateOrCountry>
      <signatureDate>11-14-2025</signatureDate>
    </signatureBlock>
    <summaryPage>
      <otherIncludedManagersCount>0</otherIncludedManagersCount>
      <tableEntryTotal>33</tableEntryTotal>
      <tableValueTotal>1776690536</tableValueTotal>
      <isConfidentialOmitted>false</isConfidentialOmitted>
    </summaryPage>
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