The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F COVER PAGE

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Report for the Calendar Year or Quarter Ended: 06-30-2022
Check here if Amendment X Amendment Number: 1
This Amendment (Check only one.): X is a restatement.
   adds new holdings entries.
Institutional Investment Manager Filing this Report:
Name: VR Adviser, LLC
Address: 7 Bryant Park
23rd Floor
New York, NY  10018
Form 13F File Number: 028-20281
CRD Number (if applicable):
SEC File Number (if applicable):

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.

Person Signing this Report on Behalf of Reporting Manager:
Name: Sherman G. Souther
Title: Authorized Signatory
Phone: 650-561-9580
Signature, Place, and Date of Signing:
/s/ Sherman G. Souther Palo AltoCA 05-15-2023
[Signature] [City, State] [Date]
Note: VR Adviser, LLC is filing this Form 13F on behalf of itself and the general partner entities of the investment funds for which it serves as the investment adviser, VHCP Management II, LLC, VHCP Management III, LLC and VHCP Management EG, LLC. Note: This amendment is being filed solely to remove holdings of securities of DBV Technologies S A ("DBV") from the reporting manager's holdings of 13(f) securities as of June 30, 2022. The reporting manager's holdings of DBV equity securities as of June 30, 2022 consisted of ordinary shares, which are not considered "Section 13(f) securities" and are, therefore, not reportable on Form 13F, in contrast to American depositary shares, which are reportable on Form 13F. This amendment does not reflect the disposition of any securities of DBV by the reporting manager, but merely reflects the fact that the holdings as of June 30, 2022 were in the form of ordinary shares. As of June 30, 2022, the reporting manager's holdings included 9,300,000 ordinary shares of DBV.
Report Type (Check only one.):
X 13F HOLDINGS REPORT. (Check here if all holdings of this reporting manager are reported in this report.)
   13F NOTICE. (Check here if no holdings reported are in this report, and all holdings are reported by other reporting manager(s).)
   13F COMBINATION REPORT. (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)
Form 13F Summary Page
Report Summary:
Number of Other Included Managers: 0
Form 13F Information Table Entry Total: 27
Form 13F Information Table Value Total: 507,777,000
(round to nearest dollar)
List of Other Included Managers:
Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.
[If there are no entries in this list, state “NONE” and omit the column headings and list entries.]
NONE