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  <headerData>
    <submissionType>13F-HR</submissionType>
    <filerInfo>
      <liveTestFlag>LIVE</liveTestFlag>
      <flags>
        <confirmingCopyFlag>false</confirmingCopyFlag>
        <returnCopyFlag>false</returnCopyFlag>
        <overrideInternetFlag>false</overrideInternetFlag>
      </flags>
      <filer>
        <credentials>
          <cik>0001615982</cik>
          <ccc>XXXXXXXX</ccc>
        </credentials>
      </filer>
      <periodOfReport>03-31-2022</periodOfReport>
    </filerInfo>
  </headerData>
  <formData>
    <coverPage>
      <reportCalendarOrQuarter>03-31-2022</reportCalendarOrQuarter>
      <isAmendment>false</isAmendment>
      <filingManager>
        <name>VR Adviser, LLC</name>
        <address>
          <ns1:street1>7 Bryant Park</ns1:street1>
          <ns1:street2>23rd Floor</ns1:street2>
          <ns1:city>New York</ns1:city>
          <ns1:stateOrCountry>NY</ns1:stateOrCountry>
          <ns1:zipCode>10018</ns1:zipCode>
        </address>
      </filingManager>
      <reportType>13F HOLDINGS REPORT</reportType>
      <form13FFileNumber>028-20281</form13FFileNumber>
      <provideInfoForInstruction5>Y</provideInfoForInstruction5>
      <additionalInformation>Note: VR Adviser, LLC is filing this Form 13F on behalf of itself and the general partner entities of the investment funds for which it serves as the investment adviser, VHCP Management II, LLC, VHCP Management III, LLC and VHCP Management EG, LLC.</additionalInformation>
    </coverPage>
    <signatureBlock>
      <name>David L. Stepp</name>
      <title>Authorized Signatory</title>
      <phone>650-561-9580</phone>
      <signature>/s/ David L. Stepp</signature>
      <city>Palo Alto</city>
      <stateOrCountry>CA</stateOrCountry>
      <signatureDate>05-16-2022</signatureDate>
    </signatureBlock>
    <summaryPage>
      <otherIncludedManagersCount>0</otherIncludedManagersCount>
      <tableEntryTotal>27</tableEntryTotal>
      <tableValueTotal>617244</tableValueTotal>
    </summaryPage>
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