Quarterly financial information (unaudited)



	First Quarter Ended March 31, 2018			Second Quarter Ended June 30, 2018			Third Quarter Ended September 30, 2018			Fourth Quarter Ended December 31, 2018
Net product revenue	$	176,255		$	241,416		$	247,284		$	161,560
Other revenue	2,327			4,086			3,707			1,507
Total revenue	178,582			245,502			250,991			163,067
Costs and expenses:
Cost of product revenue	83,934			179,945			91,937			74,934
Research and development	4,680,181			6,174,589			865,765			187,759
Selling, general and administrative	3,697,287			2,994,649			1,959,872			1,921,513
Total costs and expenses	8,461,402			9,349,183			2,917,574			2,184,206
Loss from operations	(8,282,820		)	(9,103,681		)	(2,666,583		)	(2,021,139		)
Interest income, net	59,593			51,809			28,210			12,394
Net loss	$	(8,223,227	)	$	(9,051,872	)	$	(2,638,373	)	$	(2,008,745	)
Net loss per share attributable to common stockholders — basic and diluted	$	(0.46	)	$	(0.50	)	$	(0.15	)	$	(0.11	)
Weighted-average number of common shares outstanding — basic and diluted	17,893,912			18,037,274			18,066,548			18,067,179



	First Quarter Ended March 31, 2017			Second Quarter Ended June 30, 2017			Third Quarter Ended September 30, 2017			Fourth Quarter Ended December 31, 2017
Net product revenue	$	240,292		$	330,688		$	407,241		$	282,752
Other revenue	2,255			4,835			6,360			76
Total revenue	242,547			335,523			413,601			282,828
Costs and expenses:
Cost of product revenue	79,106			145,325			148,756			133,343
Research and development	3,914,974			4,076,220			4,739,360			4,259,357
Selling, general and administrative	4,594,716			4,990,943			4,934,937			3,983,088
Total costs and expenses	8,588,796			9,212,488			9,823,053			8,375,788
Loss from operations	(8,346,249		)	(8,876,965		)	(9,409,452		)	(8,092,960		)
Interest income, net	77,854			72,342			77,339			64,429
Net loss	$	(8,268,395	)	$	(8,804,623	)	$	(9,332,113	)	$	(8,028,531	)
Net loss per share attributable to common stockholders — basic and diluted	$	(0.49	)	$	(0.51	)	$	(0.54	)	$	(0.46	)
Weighted-average number of common shares outstanding — basic and diluted	16,873,512			17,130,264			17,386,249			17,642,646

On January 1, 2018, the Company adopted ASC 606 using the modified retrospective method applied to contracts not yet completed as of January 1, 2018. Results for reporting periods beginning after January 1, 2018 are presented under ASC 606, while prior period amounts are not adjusted and are reported in accordance with the Company's historical accounting under ASC 605.

The Company would have recognized approximately $18,000, $10,000, $1,000 and $15,000 of additional total revenue during the quarters ended March 31, 2018, June 30, 2018, September 30, 2018 and December 31, 2018, respectively, if the Company had continued to recognize revenue under ASC 605.