X0306 4 2021-10-12 0 0001615055 IsoPlexis Corp ISO 0001871669 Northpond Capital GP, LLC 7500 OLD GEORGETOWN ROAD SUITE 850 BETHESDA MD 20814 0 0 1 0 0001871659 Northpond Capital, L.P. 7500 OLD GEORGETOWN ROAD SUITE 850 BETHESDA MD 20814 0 0 1 0 0001867470 Northpond Ventures GP, LLC 7500 OLD GEORGETOWN ROAD SUITE 850 BETHESDA MD 20814 0 0 1 0 0001867472 Northpond Ventures, LP 7500 OLD GEORGETOWN ROAD SUITE 850 BETHESDA MD 20814 0 0 1 0 0001867627 Rubin Michael P. C/O NORTHPOND VENTURES 7500 OLD GEORGETOWN ROAD, SUITE 850 BETHESDA MD 20814 0 0 1 0 Common Stock 2021-10-12 4 C 0 6304192 A 6727570 I See footnote Common Stock 2021-10-12 4 C 0 1040048 A 1080961 I See footnote Common Stock 2021-10-12 4 P 0 1000000 15.00 A 2080961 I See footnote Series C Redeemable Convertible Preferred Stock 2021-10-12 4 C 0 287785 0.00 D Common Stock 2302280 0 I See footnote Series C-2 Redeemable Convertible Preferred Stock 2021-10-12 4 C 0 309131 0.00 D Common Stock 2473048 0 I See footnote Series D Redeemable Convertible Preferred Stock 2021-10-12 4 C 0 191108 0.00 D Common Stock 1528864 0 I See footnote Series D Redeemable Convertible Preferred Stock 2021-10-12 4 C 0 130006 0.00 D Common Stock 1040048 0 I See footnote Each share of the Series C Redeemable Convertible Preferred Stock, Series C-2 Redeemable Convertible Preferred Stock and Series D Redeemable Convertible Preferred Stock automatically converted on a one-for-8 basis into Common Stock upon the consummation of the Issuer's initial public offering. The preferred stock had no expiration date. Includes 423,378 shares of Common Stock issued per dividends accrued to but not including October 12, 2021. The securities are held directly by Northpond Ventures, LP ("Northpond"). Northpond Ventures GP, LLC ("Northpond GP") is the general partner of Northpond. Michael P. Rubin ("Rubin") is the managing member of Northpond GP. Includes 40,913 shares of Common Stock issued per dividends accrued to but not including October 12, 2021. The securities are held directly by Northpond Capital, LP ("Northpond Capital"). Northpond Capital GP, LLC ("Northpond Capital GP") is the general partner of Northpond Capital. Rubin is the managing member of Northpond Capital GP. Northpond Capital GP, LLC, By: /s/ Patrick Smerkers, Senior Vice President, Finance and Operations 2021-10-14 Northpond Capital, LP, By: Northpond Capital GP, LLC, its general partner, By: /s/ Patrick Smerkers, Senior Vice President, Finance and Operations 2021-10-14 Northpond Ventures GP, LLC, By: /s/ Patrick Smerkers, Senior Vice President, Finance and Operations 2021-10-14 Northpond Ventures, LP, By: Northpond Ventures GP, LLC, its general partner, By: /s/ Patrick Smerkers, Senior Vice President, Finance and Operations 2021-10-14 /s/ Michael P. Rubin 2021-10-14