144 0001614821 XXXXXXXX LIVE 0001484565 SOLENO THERAPEUTICS INC 001-36593 100 MARINE PARKWAY, SUITE 400 REDWOOD CITY CA 94065 650-213-8444 Bhatnagar Anish Officer Director Common Stock ETrade Financial Corporation

P.O. Box 484 Jersey City NJ 07303

746041 37339352.05 45857291 03/27/2025 NASDAQ Common Stock 03/26/2025 Vesting of Restricted Stock Units - See Remarks Issuer N 233750 03/26/2025 Equity Compensation Common Stock 03/27/2025 Stock option exercises Issuer N 512291 03/27/2025 Cash N Anish Bhatgagar

c/o Soleno Therapeutics, Inc. 100 Marine Pkwy, Suite 400 Redwood City CA 94065

Common Stock 01/02/2025 10937 496640.35 Anish Bhatnagar

c/o Soleno Therapeutics, Inc. 100 Marine Pkwy, Suite 400 Redwood City CA 94065

Common Stock 01/03/2025 10154 468875.17 Approximately 233,750 shares to be sold to cover tax withholding obligations in connection with the vesting of restricted stock units. 03/27/2025 /s/ Anish Bhatnagar