X0306 4 2022-01-28 0 0001484565 SOLENO THERAPEUTICS INC SLNO 0001614821 Anish Bhatnagar 203 REDWOOD SHORES PKWY, STE 500 REDWOOD CITY CA 94065 1 1 0 0 See Remarks Employee stock option (right to buy) 0.34 2022-01-28 4 A 0 610000 0.00 A 2032-01-28 Common Stock 610000 610000 D One forty-eighth (1/48th) of the shares subject to the Option shall vest on the first month anniversary of Vesting Commencement Date (January 1, 2022), and one forty-eighth (1/48th) of the total number of shares subject to the Option shall vest each month thereafter on the same day of the month as the Vesting Commencement Date (and if there is no corresponding day, on the last day of the month), such that all of the shares subject to the Option will have vested as of the fourth anniversary of the Vesting Commencement Date, subject to Reporting Person continuing to be a Service Provider through each such date. President and Chief Executive Officer /s/ Anish Bhatnagar 2022-02-01