X0306 4/A 2021-01-23 2021-01-26 0 0001484565 SOLENO THERAPEUTICS INC SLNO 0001614821 Anish Bhatnagar 203 REDWOOD SHORES PKWY, STE 500 REDWOOD CITY CA 94065 0 1 0 0 Chief Executive Officer Common Stock 2021-01-23 4 F 0 36318 2.11 D 409260 D Represents shares that have been withheld by the Issuer to satisfy its tax withholding and remittance obligations in connection with the net settlement of restricted stock units and does not represent a sale by the Reporting Person. /s/ Anish Bhatnagar 2021-01-26