X0306 4 2019-01-24 0 0001484565 SOLENO THERAPEUTICS INC SLNO 0001614821 Anish Bhatnagar 1235 RADIO ROAD, SUITE 110 REDWOOD CITY CA 94065 1 1 0 0 President and CEO Employee stock option (right to buy) 1.67 2019-01-24 4 A 0 250000 0.00 A 2029-01-24 Common Stock 250000 250000 D One forty-eighth (1/48) of the shares subject to the Option shall vest on the first month anniversary of January 24, 2019 (the "Vesting Commencement Date") and one forty-eighth (1/48) of the total number of shares subject to the Option shall vest each month thereafter on the same day of the month as the Vesting Commencement Date, such that all of the shares subject to the Option will have vested as of the fourth anniversary of the Vesting Commencement Date, subject to Participant continuing to be a Service Provider through each such date. /s/ Jonathan Wolter, Attorney-in-Fact 2019-01-28