X0306 4 2022-05-09 0 0001082038 DURECT CORP DRRX 0001614780 Farfel Gail M C/O DURECT CORPORATION 10260 BUBB ROAD CUPERTINO CA 95014 1 0 0 0 Common Stock 2022-05-09 4 P 0 17500 0.3946 A 17500 D Common Stock 2022-05-10 4 P 0 4250 0.395 A 21750 D The reported price in Column 4 is a weighted average price. These shares were purchased in multiple transactions. Prices ranged from $0.392 to $0.4078 per share, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or to the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote. /s/ Gail M. Farfel 2022-05-10