X0306 4 2021-06-10 0001681087 AVROBIO, Inc. AVRO 0001614780 Farfel Gail M C/O AVROBIO, INC. ONE KENDALL SQUARE, BLDG. 300, SUITE 201 CAMBRIDGE MA 02139 1 Stock Option (Right to Buy) 9.63 2021-06-10 4 A 0 17438 0 A 2031-06-09 Common Stock 17438 17438 D The option shall vest in full upon the earlier of June 10, 2022 or the date of the Issuer's 2022 Annual Meeting of Stockholders, subject to the reporting person's continued service as a director through such vesting date. /s/ Christopher Gerry, Attorney in Fact for Gail M. Farfel 2021-06-14