X0306 4 2015-07-01 0 0001375151 ZOGENIX, INC. ZGNX 0001614780 Farfel Gail M C/O ZOGENIX, INC. 12400 HIGH BLUFF DR., SUITE 650 SAN DIEGO CA 92130 0 1 0 0 EVP/Chief Development Officer Stock Option (Right to Buy) 13.96 2015-07-01 4 A 0 56250 0.00 A 2025-06-30 Common Stock 56250 56250 D The option was granted on July 1, 2015, which is the vesting commencement date. One-fourth of the shares subject to the option will vest on the first anniversary of the vesting commencement date, and the remaining shares subject to the option shall vest in thirty-six equal monthly installments over the three-year period thereafter, subject to the Reporting Person's continued employment with the Company on each vesting date /s/ Thomas Doyle, Attorney-in-fact 2015-07-06