X0407 4 2023-03-29 0 0001746473 PLIANT THERAPEUTICS, INC. PLRX 0001614741 Lefebvre Eric C/O PLIANT THERAPEUTICS, INC. 260 LITTLEFIELD AVENUE SOUTH SAN FRANCISCO CA 94080 0 1 0 0 Chief Medical Officer 0 Common Stock 2023-03-29 4 A 0 21874 0.00 A 157031 D On July 28, 2022, the Reporting Person was granted 87,500 performance-vested stock units, the vesting of which are subject to the achievement of various pre-established performance criteria. On March 29, 2023, the Compensation Committee of the Issuer's Board of Directors certified the achievement of an operational performance criteria, resulting in the vesting of 21,874 shares. Includes 1,231 shares of Common Stock acquired by the Reporting Person pursuant to an Employee Stock Purchase Plan program. /s/ Mike Ouimette, attorney-in-fact 2023-03-31