X0306 4 2023-01-25 0001746473 PLIANT THERAPEUTICS, INC. PLRX 0001614741 Lefebvre Eric C/O PLIANT THERAPEUTICS, INC. 260 LITTLEFIELD AVENUE SOUTH SAN FRANCISCO CA 94080 true Chief Medical Officer Common Stock 2023-01-25 4 A 0 57000 0 A 133926 D Stock Option (right to buy) 34.65 2023-01-25 4 A 0 80000 0 A 2033-01-24 Common Stock 80000 80000 D These are restricted stock units that vest in three equal annual installments beginning January 16, 2023, subject to the Reporting Person's continuous service to the Issuer on each such date. 1/48th of the shares subject to such option vest and become exercisable in substantially equal installments on each monthly anniversary of January 1, 2023, subject to the Reporting Person's continuous service to the Issuer on each such date. /s/ Mike Ouimette, attorney-in-fact 2023-01-27