X0306 4 2021-11-05 0001613103 Medtronic plc MDT 0001726709 WHITE ROBERT JOHN MEDTRONIC PLC 710 MEDTRONIC PKWY MS LC300 MINNEAPOLIS MN 55432 1 EVP & Pres. Medical Surgical Ordinary Shares 2021-11-05 4 F 0 246 122.98 D 46648 D Ordinary Shares 1500 I Family Trust The reported transaction involved the withholding of 246 shares of stock issuable upon the early vesting of an equal number of restricted stock units to pay taxes associated with the reporting person becoming retirement eligible. This balance increased by 125 shares due to exempt transactions such as dividend reinvestment and employee stock purchase plan. These securities are owned by the White Family Legacy Trust. The reporting person is the co-trustee. The reporting person disclaims beneficial ownership of these securities except to the extent of his pecuniary interest therein, and this report shall not be deemed an admission that the reporting person is the beneficial owner of such securities for Section 16 or any other purpose. /s/ Thomas L. Osteraas, attorney-in-fact 2021-11-09