X0306 4 2021-11-05 0001613103 Medtronic plc MDT 0001752060 Liddicoat John R MEDTRONIC PLC 710 MEDTRONIC PKWY, MS LC300 MINNEAPOLIS MN 55432 1 EVP & President of Americas Ordinary Shares 2021-11-05 4 F 0 139 122.98 D 42998 D The reported transaction involved the withholding of 139 shares of stock issuable upon the early vesting of an equal number of restricted stock units to pay taxes associated with the reporting person becoming retirement eligible. This balance increased by 290 shares due to exempt transactions such as dividend reinvestment and employee stock purchase plan. /s/ Thomas L. Osteraas, attorney-in-fact 2021-11-09