X0306 4 2021-11-05 0001613103 Medtronic plc MDT 0001559405 Lerman Bradley E 710 MEDTRONIC PKWY MS LC300 MINNEAPOLIS MN 55432 1 SVP General Counsel & Corp Sec Ordinary Shares 2021-11-05 4 F 0 250 122.98 D 48635 D This balance increased by 122 shares due to exempt transactions such as dividend reinvestment. The reported transaction involved the withholding of 250 shares of stock issuable upon the early vesting of an equal number of restricted stock units to pay taxes associated with the reporting person becoming retirement eligible. /s/ Thomas L. Osteraas, attorney-in-fact 2021-11-09