X0306 4 2021-06-18 0001613103 Medtronic plc MDT 0001473812 Wall Brett A. 710 MEDTRONIC PARKWAY LC300 MINNEAPOLIS MN 55432 1 EVP & Pres Neuroscience Ordinary Shares 2021-06-18 4 M 0 1168 74.84 A 22655 D Ordinary Shares 2021-06-18 4 F 0 938 123.23 D 21717 D Ordinary Shares 2021-06-21 4 S 0 115 123.50 D 21602 D Stock Option (Right to Buy) 74.84 2021-06-18 4 M 0 1168 0 D 2018-06-29 2025-01-27 Ordinary Shares 1168 6850 D The transactions reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan. This option became exercisable on June 29, 2018, subject to Medtronic plc's achievement of a pre-specified cash Earnings Per Share Growth Rate for fiscal years 2016 through 2018. /s/ Thomas L. Osteraas, attorney-in-fact 2021-06-22