X0306 4 2016-09-15 0001613103 Medtronic plc MDT 0001523102 ISHRAK OMAR 710 MEDTRONIC PKWY MS LC300 MINNEAPOLIS MN 55432 1 1 Chairman & CEO Ordinary Shares 2016-09-15 4 S 0 61925 84.932 D 565916 D The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan. The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $84.40 to $85.30, inclusive. The reporting person undertakes to provide to Medtronic plc, any security holder of Medtronic plc, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. /s/ Sarah M. Maveus, Attorney-in-fact 2016-09-19