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Commitments and Contingencies - Claims and Patent License Agreement (Details)
1 Months Ended 12 Months Ended
Oct. 26, 2018
USD ($)
Jan. 31, 2018
Jun. 30, 2015
Apr. 30, 2014
Dec. 31, 2018
EUR (€)
claim
Dec. 31, 2017
EUR (€)
Dec. 31, 2012
USD ($)
Dec. 31, 2012
EUR (€)
Commitments and Contingencies                
Shares issued in the period | €         € 84,191,000 € 25,685,000    
Claims known to management related to activities of company | claim         0      
Ionis Pharmaceuticals, Inc                
Commitments and Contingencies                
Ownership interest 18.50%              
Ionis Pharmaceuticals, Inc | Stock Purchase Agreement [Member]                
Commitments and Contingencies                
Shares issued in the period $ 2,500,000              
Ownership interest 19.90%              
Period prohibiting for disposition of ordinary shares issued 12 months              
Ionis Pharmaceuticals, Inc | Maximum | License Agreement [Member]                
Commitments and Contingencies                
Upfront payment $ 6,000,000              
Certain payments upon satisfaction of certain development and sales milestones $ 20,000,000              
Radboud University Medical Center [Member] | License Agreement [Member]                
Commitments and Contingencies                
Threshold period for terminating agreement in case of default not cured     30 days          
Radboud University Medical Center [Member] | Patent license agreement                
Commitments and Contingencies                
Threshold period for terminating agreement in case of default not cured       30 days        
Radboud University Medical Center [Member] | Minimum | License Agreement [Member]                
Commitments and Contingencies                
Threshold period for terminating agreement in case payment remains outstanding after receiving notice of the amount due     30 days          
Radboud University Medical Center [Member] | Minimum | Patent license agreement                
Commitments and Contingencies                
Threshold period for terminating agreement in case payment remains outstanding after receiving notice of the amount due       30 days        
Inserm Transfert SA and Assistance [Member] | License Agreement [Member]                
Commitments and Contingencies                
Term of agreement after the first commercial sale of a product in the country in which the product is sold   5 years            
Period for voluntary or involuntary winding-up proceedings or judicial recovery if sublicensees interrupt development activities   1 year            
Period for voluntary or involuntary winding-up proceedings or judicial recovery if sublicensees interrupt commercialization   12 months            
Period for voluntary or involuntary winding-up proceedings or judicial recovery if the entity does not commercialize a product following to obtaining of marketing approval in a country   2 years            
Period for voluntary or involuntary winding-up proceedings or judicial recovery if the entity do not put a product into commercial use and do not keep products reasonably available to the public   12 years            
General Hospital Corporation (MGH) [Member] | Patent license agreement                
Commitments and Contingencies                
Milestone payment on achievement of development and regulatory milestones             $ 700,000 € 611,000
Annual license fee             $ 10,000 € 9,000
Royalty percentage             2.00% 2.00%