Shareholders’ Equity - Share options (Details) - Stock options	12 Months Ended
Dec. 31, 2017 EUR (€) Y	Dec. 31, 2016 EUR (€) Y	Dec. 31, 2015 EUR (€) Y
Shareholders’ Equity
Compensation expenses	€ 4,024,000	€ 2,454,000	€ 1,212,000
Compensation expenses recorded in general and administrative costs	2,059,000	1,480,000	801,000
Compensation expenses recorded in research and development costs	€ 1,965,000	€ 974,000	€ 411,000
Vesting period	4 years
Vesting period percentage	25.00%
Term options	10 years
Risk-free interest rate	1.913%	1.467%	1.497%
Expected volatility	88.70%	86.30%	86.80%
Expected life in years \| Y	5	5	5

The expected volatility of the share price used to calculate the fair value of the share options granted. Expected volatility is a measure of the amount by which a price is expected to fluctuate during a period. The measure of volatility used in option pricing models is the annualised standard deviation of the continuously compounded rates of return on the share over a period of time.

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
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The option life of share options granted.

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The implied yield currently available on zero-coupon government issues of the country in whose currency the exercise price for share options granted is expressed, with a remaining term equal to the expected term of the option being valued (based on the option's remaining contractual life and taking into account the effects of expected early exercise). [Refer: Government [member]]

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Line items represent concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes of the table.

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The amount of expense arising from share-based payment transactions in which the goods or services received did not qualify for recognition as assets.

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The amount of expense arising from share-based payment transactions in which the goods or services received did not qualify for recognition as assets in general and administration.

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The amount of expense arising from share-based payment transactions in which the goods or services received did not qualify for recognition as assets in research and development.

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Period which the right to exercise an award is no longer contingent on satisfaction of either a service condition, market condition or a performance condition, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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Period from grant date that an equity-based award expires, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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Percentage of vesting of share-based compensation awards.

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