<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/schedule13g" xmlns:com="http://www.sec.gov/edgar/common">
  <schemaVersion>X0202</schemaVersion>
<headerData>
    <submissionType>SCHEDULE 13G/A</submissionType>
    <previousAccessionNumber>0001104659-26-005130</previousAccessionNumber>
    <filerInfo>
      <filer>
        <filerCredentials>
          <!-- Field: Pseudo-Tag; ID: Name; Data: Privium Fund Management B.V. -->
          <cik>0001795097</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <coverPageHeader>
      <amendmentNo>1</amendmentNo>
      <securitiesClassTitle>Ordinary Shares, nominal value EUR0.04 per share</securitiesClassTitle>
      <eventDateRequiresFilingThisStatement>07/15/2026</eventDateRequiresFilingThisStatement>
      <issuerInfo>
        <issuerCik>0001612940</issuerCik>
        <issuerName>ProQR Therapeutics N.V.</issuerName>
        <issuerCusips>
          <issuerCusipNumber>N71542109</issuerCusipNumber>
        </issuerCusips>
        <issuerPrincipalExecutiveOfficeAddress>
          <com:street1>Zernikedreef 9</com:street1>
          <com:city>Leiden</com:city>
          <com:stateOrCountry>P7</com:stateOrCountry>
          <com:zipCode>CK 2333</com:zipCode>
        </issuerPrincipalExecutiveOfficeAddress>
      </issuerInfo>
      <designateRulesPursuantThisScheduleFiled>
        <designateRulePursuantThisScheduleFiled>Rule 13d-1(c)</designateRulePursuantThisScheduleFiled>
      </designateRulesPursuantThisScheduleFiled>
    </coverPageHeader>
    <coverPageHeaderReportingPersonDetails>

      <reportingPersonName>STICHTING AESCAP LIFE SCIENCES</reportingPersonName>
      <citizenshipOrOrganization>P7</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>4156878.00</soleVotingPower>
        <sharedVotingPower>0.00</sharedVotingPower>
        <soleDispositivePower>4156878.00</soleDispositivePower>
        <sharedDispositivePower>0.00</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>4156878.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>2.95</classPercent>
      <typeOfReportingPerson>FI</typeOfReportingPerson>
      <comments>(1) Based upon 141,121,476 ordinary shares outstanding</comments>
    </coverPageHeaderReportingPersonDetails>
    <coverPageHeaderReportingPersonDetails>


      <reportingPersonName>PRIVIUM FUND MANAGEMENT B.V.</reportingPersonName>
      <citizenshipOrOrganization>P7</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>5467149.00</soleVotingPower>
        <sharedVotingPower>0.00</sharedVotingPower>
        <soleDispositivePower>5467149.00</soleDispositivePower>
        <sharedDispositivePower>0.00</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>5467149.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>3.87</classPercent>
      <typeOfReportingPerson>FI</typeOfReportingPerson>
      <comments>(1) Based upon 141,121,476 ordinary shares outstanding</comments>
    </coverPageHeaderReportingPersonDetails>
    <coverPageHeaderReportingPersonDetails>

      <reportingPersonName>STICHTING AESCAP GENETICS</reportingPersonName>
      <citizenshipOrOrganization>P7</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>1310271.00</soleVotingPower>
        <sharedVotingPower>0.00</sharedVotingPower>
        <soleDispositivePower>1310271.00</soleDispositivePower>
        <sharedDispositivePower>0.00</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>1310271.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>0.93</classPercent>
      <typeOfReportingPerson>FI</typeOfReportingPerson>
      <comments>(1) Based upon 141,121,476 ordinary shares outstanding</comments>
    </coverPageHeaderReportingPersonDetails>
    <coverPageHeaderReportingPersonDetails>

      <reportingPersonName>INSPIRATIONAL VISIONS B.V.</reportingPersonName>
      <citizenshipOrOrganization>P7</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>35411.00</soleVotingPower>
        <sharedVotingPower>0.00</sharedVotingPower>
        <soleDispositivePower>35411.00</soleDispositivePower>
        <sharedDispositivePower>0.00</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>35411.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>0.03</classPercent>
      <typeOfReportingPerson>FI</typeOfReportingPerson>
      <comments>(1) Based upon 141,121,476 ordinary shares outstanding</comments>
    </coverPageHeaderReportingPersonDetails>
    <coverPageHeaderReportingPersonDetails>

      <reportingPersonName>PATRICK JOHAN HENDRIK KROL</reportingPersonName>
      <citizenshipOrOrganization>P7</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>5528862.00</soleVotingPower>
        <sharedVotingPower>0.00</sharedVotingPower>
        <soleDispositivePower>5528862.00</soleDispositivePower>
        <sharedDispositivePower>0.00</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>5528862.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>5.2</classPercent>
      <typeOfReportingPerson>FI</typeOfReportingPerson>
      <comments>(1) Based upon 141,121,476 ordinary shares outstanding</comments>
    </coverPageHeaderReportingPersonDetails>
    <items>
      <item1>
        <issuerName>ProQR Therapeutics N.V.</issuerName>
        <issuerPrincipalExecutiveOfficeAddress>Zernikedreef 9, Leiden, The Netherlands CK 2333</issuerPrincipalExecutiveOfficeAddress>
      </item1>
      <item2>
        <filingPersonName>(i) Stichting Aescap Life Sciences ("Aescap Life Sciences")

(ii) Privium Fund Management B.V. ("Privium"), as the fund manager of Aescap Life Sciences

(iii) Stichting Aescap Genetics ("Aescap Genetics")

(iv) Inspirational Visions BV ("Inspirational Visions")

(v) Patrick Johan Hendrik Krol ("Krol"), the portfolio manager for Privium regarding Aescap Life Sciences and Aescap Genetics and the managing director of Inspirational Visions

The foregoing persons are hereinafter sometimes collectively referred to as the "Reporting Persons."</filingPersonName>
        <principalBusinessOfficeOrResidenceAddress>The principal business address of each of Aescap Life Sciences, Privium, Aescap Genetics and Krol is:

Gustav Mahlerplein 3
1082 MS Amsterdam
The Netherlands

The principal business address of Inspirational Visions is:

A.J. Ernststraat 595-C
1082 LN Amsterdam
The Netherlands</principalBusinessOfficeOrResidenceAddress>
        <citizenship>The citizenship of each of the Reporting Persons is the Netherlands.</citizenship>
      </item2>
      <item3>
        <notApplicableFlag>Y</notApplicableFlag>
      </item3>
      <item4>
        <amountBeneficiallyOwned>As its Fund Manager, the Shares held by Aescap Life Sciences may be deemed to be beneficially
owned by Privium. In addition, as its Fund Manager, the Shares held by Aescap Genetics may be
deemed to be beneficially owned by Privium. As the portfolio manager of Privium, Krol may be deemed
to beneficially own the Shares held by Aescap Life Sciences and Aescap Genetics. In addition, as the
managing director of Inspirational Visions, Krol may be deemed to beneficially own the Shares held by
Inspirational Visions.

As of the date of this report, Aescap Life Sciences directly held 4,156,878 Shares. As of the date of this
report, Aescap Genetics directly held 1,310,271 Shares. As of the date of this report, Inspirational
Visions directly held 35,411 Shares. As of the date of this report, Krol directly held 26,302 Shares.</amountBeneficiallyOwned>
        <classPercent>Aescap Life Sciences may be deemed the beneficial owner of approximately 2.95% of the Shares outstanding.

Privium may be deemed the beneficial owner of approximately 3.87% of the Shares outstanding.

Aescap Genetics may be deemed the beneficial owner of approximately 0.93% of the Shares outstanding.

Inspirational Visions may be deemed the beneficial owner of approximately 0.03% of the Shares outstanding.

Krol may be deemed the beneficial owner of approximately 3.92% of the Shares outstanding.</classPercent>
        <numberOfSharesPersonHas>
          <solePowerOrDirectToVote>Aescap Life Sciences: 4,156,878

Privium: 5,467,149

Aescap Genetics: 1,310,271

Inspirational Visions: 35,411

Krol: 5,528,862</solePowerOrDirectToVote>
          <sharedPowerOrDirectToVote>Aescap Life Sciences: 0

Privium: 0

Aescap Genetics: 0

Inspirational Visions: 0

Krol: 0</sharedPowerOrDirectToVote>
          <solePowerOrDirectToDispose>Aescap Life Sciences: 4,156,878

Privium: 5,467,149

Aescap Genetics: 1,310,271

Inspirational Visions: 35,411

Krol: 5,528,862</solePowerOrDirectToDispose>
          <sharedPowerOrDirectToDispose>Aescap Life Sciences: 0

Privium: 0

Aescap Genetics: 0

Inspirational Visions: 0

Krol: 0</sharedPowerOrDirectToDispose>
        </numberOfSharesPersonHas>
      </item4>
      <item5>
        <notApplicableFlag>Y</notApplicableFlag>
      </item5>
      <item6>
        <notApplicableFlag>Y</notApplicableFlag>
      </item6>
      <item7>
        <notApplicableFlag>Y</notApplicableFlag>
      </item7>
      <item8>
        <notApplicableFlag>Y</notApplicableFlag>
      </item8>
      <item9>
        <notApplicableFlag>Y</notApplicableFlag>
      </item9>
      <item10>
        <notApplicableFlag>N</notApplicableFlag>
        <certifications>By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11.</certifications>
      </item10>
    </items>
    <exhibitInfo>Exhibit 99.1: Joint Filing Agreement (filed herewith).</exhibitInfo>
    <signatureInformation>
      <reportingPersonName>STICHTING AESCAP LIFE SCIENCES</reportingPersonName>
      <signatureDetails>
        <signature>/s/ P.J.H. Krol</signature>
        <title>P.J.H. Krol, Portfolio Manager of Privium Fund Management B.V., its Fund Manager</title>
        <date>07/15/2026</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>PRIVIUM FUND MANAGEMENT B.V.</reportingPersonName>
      <signatureDetails>
        <signature>/s/ P.J.H. Krol</signature>
        <title>P.J.H. Krol, Portfolio Manager</title>
        <date>07/15/2026</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>STICHTING AESCAP GENETICS</reportingPersonName>
      <signatureDetails>
        <signature>/s/ P.J.H. Krol</signature>
        <title>P.J.H. Krol, Portfolio Manager of Privium Fund Management B.V., its Fund Manager</title>
        <date>07/15/2026</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>INSPIRATIONAL VISIONS B.V.</reportingPersonName>
      <signatureDetails>
        <signature>/s/ P.J.H. Krol</signature>
        <title>P.J.H. Krol, Managing Director</title>
        <date>07/15/2026</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>PATRICK JOHAN HENDRIK KROL</reportingPersonName>
      <signatureDetails>
        <signature>/s/ P.J.H. Krol</signature>
        <title>P.J.H. Krol</title>
        <date>07/15/2026</date>
      </signatureDetails>
    </signatureInformation>
  </formData>

</edgarSubmission>
