SCHEDULE 13G 0001795097 XXXXXXXX LIVE Ordinary Shares, nominal value EUR0.04 per share 12/11/2025 0001612940 ProQR Therapeutics N.V. N71542109 Zernikedreef 9 Leiden P7 CK 2333 Rule 13d-1(c) STICHTING AESCAP LIFE SCIENCES P7 4156878.00 0.00 4156878.00 0.00 4156878.00 N 3.9 FI (1) Based upon 105,345,192 ordinary shares outstanding as of September 30, 2025, as disclosed in the Issuer's Report of Foreign Private Issuer on Form 6-K filed on November 6, 2025. PRIVIUM FUND MANAGEMENT B.V. P7 5467149.00 0.00 5467149.00 0.00 5467149.00 N 5.2 FI (1) Based upon 105,345,192 ordinary shares outstanding as of September 30, 2025, as disclosed in the Issuer's Report of Foreign Private Issuer on Form 6-K filed on November 6, 2025. STICHTING AESCAP GENETICS P7 1310271.00 0.00 1310271.00 0.00 1310271.00 N 1.2 FI (1) Based upon 105,345,192 ordinary shares outstanding as of September 30, 2025, as disclosed in the Issuer's Report of Foreign Private Issuer on Form 6-K filed on November 6, 2025. INSPIRATIONAL VISIONS B.V. P7 35411.00 0.00 35411.00 0.00 35411.00 N 0.1 FI (1) Based upon 105,345,192 ordinary shares outstanding as of September 30, 2025, as disclosed in the Issuer's Report of Foreign Private Issuer on Form 6-K filed on November 6, 2025. PATRICK JOHAN HENDRIK KROL P7 5528862.00 0.00 5528862.00 0.00 5528862.00 N 5.2 FI (1) Based upon 105,345,192 ordinary shares outstanding as of September 30, 2025, as disclosed in the Issuer's Report of Foreign Private Issuer on Form 6-K filed on November 6, 2025. ProQR Therapeutics N.V. Zernikedreef 9 Leiden, The Netherlands, CK 2333 (i) Stichting Aescap Life Sciences ("Aescap Life Sciences") (ii) Privium Fund Management B.V. ("Privium"), as the fund manager of Aescap Life Sciences (iii) Stichting Aescap Genetics ("Aescap Genetics") (iv) Inspirational Visions BV ("Inspirational Visions") (v) Patrick Johan Hendrik Krol ("Krol"), the portfolio manager for Privium regarding Aescap Life Sciences and Aescap Genetics and the managing director of Inspirational Visions The foregoing persons are hereinafter sometimes collectively referred to as the "Reporting Persons." The principal business address of each of Aescap Life Sciences, Privium, Aescap Genetics and Krol is: Gustav Mahlerplein 3 1082 MS Amsterdam The Netherlands The principal business address of Inspirational Visions is: A.J. Ernststraat 595-C 1082 LN Amsterdam The Netherlands The citizenship of each of the Reporting Persons is the Netherlands. Y As its Fund Manager, the Shares held by Aescap Life Sciences may be deemed to be beneficially owned by Privium. In addition, as its Fund Manager, the Shares held by Aescap Genetics may be deemed to be beneficially owned by Privium. As the portfolio manager of Privium, Krol may be deemed to beneficially own the Shares held by Aescap Life Sciences and Aescap Genetics. In addition, as the managing director of Inspirational Visions, Krol may be deemed to beneficially own the Shares held by Inspirational Visions. As of the date of this report, Aescap Life Sciences directly held 4,156,878 Shares. As of the date of this report, Aescap Genetics directly held 1,310,271 Shares. As of the date of this report, Inspirational Visions directly held 35,411 Shares. As of the date of this report, Krol directly held 26,302 Shares. Aescap Life Sciences may be deemed the beneficial owner of approximately 3.9% of the Shares outstanding. Privium may be deemed the beneficial owner of approximately 5.2% of the Shares outstanding. Aescap Genetics may be deemed the beneficial owner of approximately 1.2% of the Shares outstanding. Inspirational Visions may be deemed the beneficial owner of approximately 0.1% of the Shares outstanding. Krol may be deemed the beneficial owner of approximately 5.2% of the Shares outstanding. Aescap Life Sciences: 4,156,878 Privium: 5,467,149 Aescap Genetics: 1,310,271 Inspirational Visions: 35,411 Krol: 5,528,862 Aescap Life Sciences: 0 Privium: 0 Aescap Genetics: 0 Inspirational Visions: 0 Krol: 0 Aescap Life Sciences: 4,156,878 Privium: 5,467,149 Aescap Genetics: 1,310,271 Inspirational Visions: 35,411 Krol: 5,528,862 Aescap Life Sciences: 0 Privium: 0 Aescap Genetics: 0 Inspirational Visions: 0 Krol: 0 Y Y Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. Exhibit 99.1: Joint Filing Agreement (filed herewith). STICHTING AESCAP LIFE SCIENCES /s/ P.J.H. Krol 01/20/2026 PRIVIUM FUND MANAGEMENT B.V. /s/ P.J.H. Krol 01/20/2026 STICHTING AESCAP GENETICS /s/ P.J.H. Krol 01/20/2026 INSPIRATIONAL VISIONS B.V. /s/ P.J.H. Krol 01/20/2026 PATRICK JOHAN HENDRIK KROL /s/ P.J.H. Krol 01/20/2026