X0306 4 2018-09-28 0 0001724344 Entasis Therapeutics Holdings Inc. ETTX 0001612133 Sofinnova Venture Partners IX, L.P. C/O SOFINNOVA VENTURES, INC. 3000 SAND HILL ROAD, BLDG. 4, SUITE 250 MENLO PARK CA 94025 0 0 1 0 0001612134 Sofinnova Management IX, L.L.C. C/O SOFINNOVA VENTURES, INC. 3000 SAND HILL ROAD, BLDG. 4, SUITE 250 MENLO PARK CA 94025 0 0 1 0 0001245624 HEALY JAMES C/O SOFINNOVA VENTURES, INC. 3000 SAND HILL ROAD, BLDG. 4, SUITE 250 MENLO PARK CA 94025 0 0 1 0 0001590102 Mehra Anand C/O SOFINNOVA VENTURES, INC. 3000 SAND HILL ROAD, BLDG. 4, SUITE 250 MENLO PARK CA 94025 0 0 1 0 0001202793 POWELL MICHAEL C/O SOFINNOVA VENTURES, INC 3000 SAND HILL ROAD, BLDG. 4, SUITE 250 MENLO PARK CA 94025 0 0 1 0 Common Stock 2018-09-28 4 C 0 359267 A 359267 D Common Stock 2018-09-28 4 C 0 458425 A 842454 D Common Stock 2018-09-28 4 P 0 337724 15.00 A 1180178 D Series B-1 Tranche A Convertible Preferred Stock 2018-09-28 4 C 0 7446904 0.00 D Common Stock 359267 0 D Series B-1 Tranche B Convertible Preferred Stock 2018-09-28 4 C 0 9502249 0.00 D Common Stock 458425 0 D Each share of Series B-1 Tranche A Convertible Preferred Stock and Series B-1 Tranche B Convertible Preferred Stock (collectively, the "Preferred Stock") automatically converted into Common Stock on a 20.728-for-one basis upon the closing of the Issuer's initial public offering. The Preferred Stock had no expiration date. The reportable shares are held of record by Sofinnova Venture Partners IX, L.P. ("SVP IX"). Sofinnova Management IX, L.L.C. ("SM IX") is the general partner of SVP IX. The individual managing members of SM IX are Michael Powell, James Healy and Anand Mehra, and they may be deemed to share voting and dispositive power over the shares held by SVP IX. Such persons and entities disclaim beneficial ownership over the shares held by SVP IX except to the extent of any pecuniary interest therein. This number includes an aggregate of 24,762 shares of Common Stock received upon the conversion of the Issuer's Preferred Stock as payment of the accrued dividends through September 27, 2018. No dividends will accrue after September 27, 2018. /s/ Nathalie Auber, attorney-in-fact for Sofinnova Venture Partners IX, L.P 2018-10-02 /s/ Nathalie Auber, attorney-in-fact for Sofinnova Management IX, L.L.C. 2018-10-02 /s/ Nathalie Auber, attorney-in-fact for James I. Healy 2018-10-02 /s/ Nathalie Auber, attorney-in-fact for Anand Mehra 2018-10-02 /s/ Nathalie Auber, attorney-in-fact for Michael F. Powell 2018-10-02