X0306 4 2015-03-23 0 0001492426 Horizon Pharma plc HZNP 0001611468 Hoelscher Paul W. C/O HORIZON PHARMA PLC CONNAUGHT HOUSE, 1ST FL, 1 BURLINGTON RD DUBLIN L2 4 IRELAND 0 1 0 0 EVP, CFO Stock Option (Right to Buy) 22.14 2015-03-23 4 A 0 276000 0.00 A 2025-03-22 Ordinary Shares 276000 276000 D Restricted Stock Units 2015-03-23 4 A 0 124000 0.00 A Ordinary Shares 124000 124000 D Performance Share Units (PSU) 2015-03-23 4 A 0 233000 0.00 A Ordinary Shares 233000 233000 D 25% of the shares subject to the option vest and become exercisable on the first anniversary of the date of grant, and the remaining shares vest in 36 equal monthly installments thereafter. Each restricted stock unit represents a contingent right to receive one ordinary share of the Issuer. The restricted stock units vest 25% annually on each anniversary of the date of grant. Each PSU represents a contingent right to receive ordinary shares of the Issuer, based on the Issuer's level of total shareholder return, as measured on December 22, 2017, March 22, 2018 and June 22, 2018 or based on the level of total shareholder return through any earlier change in control. For such purposes, total shareholder return means the percentage change in the price of the Issuer's ordinary shares on a compounded annual basis, plus the value of reinvested dividends. The number of shares issued may range from zero (0) shares to the maximum number of shares reported in columns 7 and 9 of this report. /s/ Paul W. Hoelscher 2015-03-25