Exhibit 5.1

Telephone: 03-6944111

Fax: 03-6091116

Reuven Behar Amir Chen Avraham Well Dr. Gil Orion Israel Fischer Ronald Lehmann Eran Yaniv Atir Jaffe Tal Eyal-Boger Yoram Bonen Raz Tepper Tamar Turjeman-Kedem Anat Shavit Michal Faktor Meital Ben-Basat Tsafrir Negbi Miri Kimhi-Goldstein Gilad Winkler Talya Solomon Orit Malka Oded Revivo Behir Sabban Shay Teken Ron Sitton Shay Adulam Israel Markovitz Sagi Hammer Dan Tzafrir Boaz Noiman Nitzan Sandor Omri Shilo Shelly Ivgi-Golbery Liat Halperin Amit Dat Dror Matatyahu Hila Zonder Messa Merav Shivek Liat Volanovsky-neuman Shiry Trifon Sharon Rosen Efrat Sharon Warren Wienburg Michal Nissani Ofer Priel Sivan Omer Michal Sela Sagi Katz Gali Friedhof Moran Friedman Hadar Sive Ayana Neumann Noya Kislev Michal Tamar Dar Lahav Itay Maoz Yoav Hovav Sharon Klein-Manbar Naama Gil Shir Or Royi Steinmetz Orit Hirschbrand Etti Dolev Yasmin Rubin Nirit Henig Shai Zadik Reut Arviv Elad Shulman Noa Barhum Barak Glickman Tal Wiesengrun Ziv Schwartz Yael Riemer Ranit Waldman Elad Offek Meirav Bar-Zik Ofira Alon Hagit Horowitz Gilad Tuffias Izick Vatensteen Vered Oren Maayan Snir Shira Gillat Ori Avni Yael Shimon-Many Dikla Lavy-Fischer Nohar Bresler Moran Rabbia Perera Roi Warhaftig Shalom Hershkovitz Asaf Gabay Arik Kaufman Tania Cohen Gabriella Strihan Eldad Meller Vardit Zigelbaum Oshrat Mor-Barak Lital Joseph Michal Shnapp Gilad Idisis Ori Shlomai Keren Cohen Tali Delouya Reut Goldstein Keren Alon Meiran Sandelson Zamir Ben Basat Moran Rom Doron Rentsler Hagar Keren-Hackim Nadav Oberman Oz Cohen Lior Bechar Hila Gabay Dana Lahav Doron Kol Hilla Sachs Michal Brandel Itiel Ben Haim Esther Logvinsky Jonathan Braverman Carolyn Zeimer Tsachi Hoftman Oren Shalom Hagar Nagler Moshe Moyal Naama Moshe Keren Shvartzberg Abigail Faust-Grossman Amir Pintow Omer Beer Shani Wexler Amir Varon Karin Ayalon Tali Michlin Keren Shmueli Natali Askira Zvika Itzkovich Roni Asheroff Nir Shlomi Dahan Chen Hershkovitz Shai Avital Jana Rabinovich Lihi Kushnir Mor Gorin Natalie Schneider Adi Flanter Rona Carp Oranit Sofer-Rubin Nadav Zohar Tslil Bainvol Amit Bechler Omer Shani Yonatan Raskin Shiran  Cohen Romy Martin Michael Lahmy Inbal Borosh Dana Goldstein Shelly Groisman Guy Engel Zohar Haim                       Shoni Albeck - Adviser Isachar Fischer 1929-2013

April 13, 2015

Check-Cap Ltd.

Check-Cap Building

Abba Hushi Avenue

P.O. Box 1271

Isfiya, 30090

Mount Carmel, Israel

Re: Check-Cap Ltd.

Ladies and Gentlemen:

We have acted as Israeli counsel to Check-Cap Ltd., a company organized under the laws of the State of Israel (the “Company”), in connection with its registration statement on Form S-8 (the “Registration Statement”) filed with the Securities and Exchange Commission under the Securities Act of 1933, as amended (the “Securities Act”) covering up to 3,714,632 ordinary shares, par value NIS 0.20 per share, of the Company (collectively, the “Shares”), authorized for issuance under the Check-Cap, LLC 2006 Unit Option Plan, as amended (the “Plan”).

In rendering the opinion expressed herein, we have examined the originals, or photocopies or copies, certified or otherwise identified to our satisfaction, of: (i) the Plan; (ii) the Articles of Association of the Company, as currently in effect; and (iii) such other corporate records, resolutions, minutes, agreements, documents and other instruments, and such certificates or comparable documents of public officials and of officers and representatives of the Company as we have deemed relevant and necessary as a basis for this opinion.  We have also made inquiries of such officers and representatives as to factual matters as we have deemed relevant and necessary as a basis for this opinion.

3 Daniel Frisch Street      Tel Aviv 64731 Israel Tel: 972-3-694-4111      Fax: 972-3-609-1116  www.fbclawyers.com

     In such examination, we have assumed the genuineness of all signatures, the legal capacity of all natural persons, the authenticity of all documents submitted to us as originals, the conformity to original documents of all documents submitted to us as reproduced or certified copies, and the authenticity of the originals of such latter documents.  We have assumed the same to have been properly given and to be accurate.  We have also assumed the truth of all facts communicated to us by the Company and that all consents, minutes and protocols of meetings of the Company’s board of directors which have been provided to us are true and accurate and have been properly prepared in accordance with the Company’s Articles of Association (as amended) and all applicable laws.  In addition, we have assumed that the Company will receive the full consideration for the Shares (which may consist, in part or in full, of services performed for the Company).

Members of our firm are admitted to the Bar in the State of Israel, and we do not express any opinion as to the laws of any other jurisdiction.  This opinion is limited to the matters stated herein and no opinion is implied or may be inferred beyond the matters expressly stated.

Based upon and subject to the foregoing and to the assumptions and qualifications set forth herein, we are of the opinion that the Shares have been duly authorized and reserved for issuance and, when issued and paid for in accordance with the terms of the Plan and the grants thereunder, will be legally issued, fully paid and non-assessable.

We hereby consent to the filing of this opinion as an exhibit to the Registration Statement.  In giving such consent, we do not thereby admit that we are in the category of persons whose consent is required under Section 7 of the Securities Act, or the rules and regulations promulgated thereunder.

This opinion letter is rendered as of the date hereof and we disclaim any obligation to advise you of facts, circumstances, events or developments that may be brought to our attention after the effective date of the Registration Statement that may alter, affect or modify the opinions expressed herein.

Very truly yours,

/s/ Fischer Behar Chen Well Orion & Co.

Fischer Behar Chen Well Orion & Co.

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