<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0206</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2016-12-05</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001610092</issuerCik>
        <issuerName>Diplomat Pharmacy, Inc.</issuerName>
        <issuerTradingSymbol>DPLO</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001691955</rptOwnerCik>
            <rptOwnerName>Rice Gary</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O DIPLOMAT PHARMACY, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>4100 SOUTH SAGINAW STREET</rptOwnerStreet2>
            <rptOwnerCity>FLINT</rptOwnerCity>
            <rptOwnerState>MI</rptOwnerState>
            <rptOwnerZipCode>48507</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>EVP of Operations</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <derivativeTable>
        <derivativeHolding>
            <securityTitle>
                <value>Employee Stock Option to Acquire Common Stock</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>4.29</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <footnoteId id="F1"/>
            </exerciseDate>
            <expirationDate>
                <value>2022-03-01</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>27313</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
        <derivativeHolding>
            <securityTitle>
                <value>Employee Stock Option to Acquire Common Stock</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>5.88</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <footnoteId id="F2"/>
            </exerciseDate>
            <expirationDate>
                <value>2023-01-15</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>131687</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
        <derivativeHolding>
            <securityTitle>
                <value>Employee Stock Option to Acquire Common Stock</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>39.26</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <footnoteId id="F3"/>
            </exerciseDate>
            <expirationDate>
                <value>2025-06-05</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>9095</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
        <derivativeHolding>
            <securityTitle>
                <value>Employee Stock Option to Acquire Common Stock</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>28.11</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <footnoteId id="F4"/>
            </exerciseDate>
            <expirationDate>
                <value>2025-10-30</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>75000</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
        <derivativeHolding>
            <securityTitle>
                <value>Employee Stock Option to Acquire Common Stock</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>25.92</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <footnoteId id="F5"/>
            </exerciseDate>
            <expirationDate>
                <value>2026-03-21</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>12467</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">The options were granted on March 1, 2012 and are fully vested.</footnote>
        <footnote id="F2">The options were granted on January 15, 2013.  The options began to vest in annual increments of 25% of the option grant on the one-year anniversary of the grant date, to be fully vested after four years.  75% of the options originally granted are currently vested and exercisable.</footnote>
        <footnote id="F3">The options were granted on June 5, 2015.  The options began to vest 25% upon determination in March 2016 of the achievement of certain performance criteria and will continue to vest in annual increments of 25% thereafter.  25% of the options originally granted are currently vested and exercisable.</footnote>
        <footnote id="F4">The options were granted on October 30, 2015.  The options began to vest in annual increments of 25% of the option grant on the one-year anniversary of the grant date, to be fully vested after four years.  25% of the options originally granted are currently vested and exercisable.</footnote>
        <footnote id="F5">The options were granted on March 21, 2016, and vest according to certain financial performance criteria of the Company.  To the extent such criteria are met, 25% will vest on approximately March 31, 2017, and the remaining options will continue to vest in annual increments of 25% thereafter.</footnote>
    </footnotes>

    <remarks>Exhibit 24, Power of Attorney, is attached.</remarks>

    <ownerSignature>
        <signatureName>Jeffrey H. Kuras, by Power of Attorney</signatureName>
        <signatureDate>2016-12-09</signatureDate>
    </ownerSignature>
</ownershipDocument>
