X0206 3 2017-08-10 0 0001590750 MIRAGEN THERAPEUTICS, INC. MGEN 0001609879 Hatfield Jeffrey S. C/O MIRAGEN THERAPEUTICS, INC. 6200 LOOKOUT ROAD BOULDER CO 80301 1 0 0 0 Stock Option (right to buy) 11.12 2027-08-09 Common Stock 24000 D Automatic non-discretionary grant to the Reporting Person of a nonstatutory stock option under the Issuer's 2016 Equity Incentive Plan (the "Plan") in accordance with the Issuer's Amended and Restated Non-Employee Director Compensation Policy. The shares shall vest in 36 equal monthly installments starting on September 10, 2017, provided that at the relevant vesting dates the Reporting Person's continuous service to the Issuer has not been terminated as defined in and as determined under the Plan. The option expires ten years after the date of grant. Exhibit List: Exhibit 24 Power of Attorney. /s/ Brent D. Fassett, As Attorney-in-Fact for Jeffrey S. Hatfield 2017-08-11