Nature of the Business and Basis of Presentation - Additional Information (Detail) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2021	Mar. 31, 2020	Dec. 31, 2020
Organization Consolidation And Presentation Of Financial Statements [Abstract]
Entity incorporated month and year	2010-10
Entity incorporation, state or country code	DE
Accumulated deficit	$ 584,241		$ 548,776
Net loss	(35,465)	$ (19,881)
Cash used in operations	(29,496)	$ (24,251)
Cash, cash equivalents and investments	$ 272,549