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Related Party Transactions - Additional Information (Detail) - USD ($)
12 Months Ended
Dec. 31, 2019
Dec. 31, 2018
Dec. 31, 2017
Feb. 29, 2016
Related Party Transaction [Line Items]        
Collaboration revenue - related party $ 27,188,000 $ 26,917,000 $ 32,100,000  
Sublease income 890,000      
Nestlé Health Science [Member]        
Related Party Transaction [Line Items]        
Collaboration revenue - related party 27,188,000 26,917,000 $ 32,100,000  
Deferred revenue 110,071,000 $ 137,259,000   $ 120,000,000
Payments under agreements with related party 0      
Due from related party for the reimbursement of development costs $ 0      
Flagship Pioneering [Member] | Sublease Agreement [Member]        
Related Party Transaction [Line Items]        
Sub lease commencement date 2019-07      
Lessee, operating sublease, existence of option to extend false      
Lessee, operating sublease, option to extend, description The term of the sublease agreement commenced in July 2019 and ends on the last day of the 24th calendar month following commencement, with no option to extend      
Cash received from related party transaction $ 890,000      
Flagship Pioneering [Member] | Sublease Agreement [Member] | Other Income [Member]        
Related Party Transaction [Line Items]        
Sublease income $ 890,000