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Related Party Transactions - Additional Information (Detail) - USD ($)
1 Months Ended 3 Months Ended 9 Months Ended
Jul. 31, 2019
Sep. 30, 2019
Sep. 30, 2018
Sep. 30, 2019
Sep. 30, 2018
Feb. 29, 2016
Related Party Transaction [Line Items]            
Collaboration revenue - related party   $ 4,840,000 $ 8,684,000 $ 21,909,000 $ 16,721,000  
Sublease income   439,000   439,000    
Nestlé Health Science [Member]            
Related Party Transaction [Line Items]            
Collaboration revenue - related party   4,840,000 8,684,000 21,909,000 16,721,000  
Deferred revenue   115,350,000   115,350,000   $ 120,000,000
Payments under agreements with related party   0 $ 0 0 $ 0  
Due from related party for the reimbursement of development costs   0   $ 0    
Flagship Pioneering [Member] | Sublease Agreement [Member]            
Related Party Transaction [Line Items]            
Sub lease commencement date 2019-07          
Lessee, operating sublease, existence of option to extend       false    
Lessee, operating sublease, option to extend, description       The term of the sublease agreement commenced in July 2019 and ends on the last day of the 24th calendar month following commencement, with no option to extend    
Cash received from related party transaction   409,000   $ 409,000    
Flagship Pioneering [Member] | Sublease Agreement [Member] | Other Income [Member]            
Related Party Transaction [Line Items]            
Sublease income   $ 439,000   $ 439,000