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Collaboration Revenue - Comparison of Reported Condensed Consolidated Statement of Operations to Pro-forma Amounts (Detail) - USD ($)
$ / shares in Units, $ in Thousands
3 Months Ended 9 Months Ended
Sep. 30, 2018
Sep. 30, 2017
Sep. 30, 2018
Sep. 30, 2017
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]        
Collaboration revenue - related party $ 8,684   $ 16,721  
Loss from operations (22,211) $ (7,314) (78,613) $ (61,620)
Net loss $ (21,949) $ (6,935) $ (77,655) $ (60,427)
Net loss per share attributable to common stockholders, basic and diluted $ (0.54) $ (0.17) $ (1.91) $ (1.49)
Previous Accounting in Effect [Member] | ASU 2014-09 [Member] | Pro Forma [Member]        
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]        
Collaboration revenue - related party $ 3,084   $ 9,167  
Loss from operations (27,811)   (86,167)  
Net loss $ (27,549)   $ (85,209)  
Net loss per share attributable to common stockholders, basic and diluted $ (0.68)   $ (2.09)