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Collaboration Revenue - Comparison of Reported Condensed Consolidated Statement of Operations to Pro-forma Amounts (Detail) - USD ($)
$ / shares in Units, $ in Thousands
3 Months Ended 6 Months Ended
Jun. 30, 2018
Jun. 30, 2017
Jun. 30, 2018
Jun. 30, 2017
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]        
Collaboration revenue - related party $ 4,271   $ 8,037  
Loss from operations (28,136) $ (28,416) (56,402) $ (54,306)
Net loss $ (27,787) $ (28,018) $ (55,706) $ (53,492)
Net loss per share attributable to common stockholders, basic and diluted $ (0.68) $ (0.69) $ (1.37) $ (1.32)
Previous Accounting in Effect [Member] | ASU 2014-09 [Member] | Pro Forma [Member]        
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]        
Collaboration revenue - related party $ 3,024   $ 6,083  
Loss from operations (29,383)   (58,356)  
Net loss $ (29,034)   $ (57,660)  
Net loss per share attributable to common stockholders, basic and diluted $ (0.71)   $ (1.42)