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Summary of Significant Accounting Policies - Additional Information (Detail) - USD ($)
1 Months Ended 12 Months Ended
Feb. 29, 2016
Jan. 31, 2016
Dec. 31, 2017
Jan. 01, 2018
Dec. 31, 2016
Accounting Policies [Line Items]          
Maximum maturity days for cash equivalents     90 days    
Restricted cash     $ 1,513,000   $ 1,400,000
Impairment losses on long lived assets     $ 0    
Minimum percentage of likelihood of tax benefit being realized upon settlement     50.00%    
ASC 606 [Member] | Subsequent Event [Member]          
Accounting Policies [Line Items]          
Cumulative effect of accounting changes made upon adoption of new accounting principle       $ 25,000,000  
Nestlé Health Science [Member]          
Accounting Policies [Line Items]          
Upfront non-refundable payment $ 120,000,000 $ 120,000,000 $ 120,000,000    
Laboratory Equipment [Member]          
Accounting Policies [Line Items]          
Useful life of asset     5 years    
Computer Equipment [Member]          
Accounting Policies [Line Items]          
Useful life of asset     3 years    
Furniture and Office Equipment [Member]          
Accounting Policies [Line Items]          
Useful life of asset     3 years