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Stockholders' Equity (Deficit) Common Stock - Common Stock Warrants - Additional Information (Detail) - USD ($)
1 Months Ended 12 Months Ended
Jun. 30, 2014
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Aug. 17, 2015
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Research and development expense for fair value of the warrant   $ 38,095,000 $ 10,718,000 $ 4,805,000  
Expected volatility   91.20% 84.00% 86.00%  
Risk-free interest rate   2.40% 2.17% 3.20%  
Expected term (in years)   8 years 2 months 12 days 8 years 8 months 12 days 9 years 8 months 12 days  
Expected dividend yield   0.00% 0.00% 0.00%  
Common Stock [Member]          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Warrants exercise price per share         $ 1.78
License Agreement Terms [Member] | Mayo Foundation [Member]          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Warrants exercise price per share $ 0.01        
Research and development expense for fair value of the warrant $ 317,000        
Expected volatility 86.00%        
Risk-free interest rate 2.30%        
Expected term (in years) 7 years        
Expected dividend yield 0.00%        
Warrant exercised date Apr. 29, 2015        
License Agreement Terms [Member] | Mayo Foundation [Member] | Performance Warrant [Member]          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Warrants issued to purchase shares of common stock   284,090      
Warrant expense $ 0        
License Agreement Terms [Member] | Mayo Foundation [Member] | Common Stock [Member]          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Warrants issued to purchase shares of common stock 454,545