Property and Equipment, Net - Schedule of Property and Equipment, Net (Detail) - USD ($) $ in Thousands	Mar. 31, 2025	Dec. 31, 2024
Property, Plant and Equipment [Line Items]
Property and equipment, gross	$ 64,819	$ 64,730
Less: Accumulated depreciation and amortization	(54,272)	(53,196)
Property and equipment, net	10,547	11,534
Laboratory Equipment [Member]
Property, Plant and Equipment [Line Items]
Property and equipment, gross	24,548	24,468
Computer Equipment [Member]
Property, Plant and Equipment [Line Items]
Property and equipment, gross	3,924	3,924
Furniture and Office Equipment [Member]
Property, Plant and Equipment [Line Items]
Property and equipment, gross	4,524	4,523
Leasehold Improvements [Member]
Property, Plant and Equipment [Line Items]
Property and equipment, gross	30,953	30,954
Construction in Progress [Member]
Property, Plant and Equipment [Line Items]
Property and equipment, gross	$ 870	$ 861