Restructuring - Additional Information (Detail) $ in Thousands		1 Months Ended	12 Months Ended
	Nov. 02, 2023 Employee	Nov. 30, 2023 USD ($)	Dec. 31, 2024 USD ($)	Dec. 31, 2023 USD ($)	Dec. 31, 2022 USD ($)
Restructuring Cost And Reserve [Line Items]
Workforce Reduction Rate	41.00%
Number of positions eliminated | Employee	160
Restructuring Charges				$ 5,606
Research and development expenses			$ 64,600	117,597	$ 109,651
General and administrative expenses			53,183	77,500	70,263
Stock-based compensation expense			$ 20,971	34,101	$ 25,482
Restructuring Charges [Member]
Restructuring Cost And Reserve [Line Items]
Research and development expenses				3,481
General and administrative expenses				2,125
Restricted Stock Units [Member]
Restructuring Cost And Reserve [Line Items]
Stock-based compensation expense		$ 1,255
Severance and other employee costs
Restructuring Cost And Reserve [Line Items]
Restructuring Charges				5,345
Acceleration of unvested equity awards
Restructuring Cost And Reserve [Line Items]
Restructuring Charges				$ 261